Effect of Curcuma longa, Piper nigrum and Berberis aristata on Ethanol and Pylorus Ligation Induced Gastric Ulcer in Rats
Abstract
Objective: To investigate the antiulcer activity of methanolic extracts of Curcuma longa, Piper nigrum and Berberis aristata in ethanol and pyloric ligation induced ulcers in rats. Material and methods: Methanolic extract of Curcuma longa (250mg/kg), Piper nigrum (250mg/kg), Berberis aristata (250mg/kg) and their combined extracts (500 mg/kg) were investigated for its potential to protect gastric mucosa against ulcers induced by ethanol and pylorus ligation method. Various parameters such as ulcer index, free acidity, total acidity and % protection were used for evaluation of anti ulcer activity. Results: Treatment with combined methanolic extracts of Curcuma longa (250mg/kg), Piper nigrum (125mg/kg) and Berberis aristata (125mg/kg) signicantly diminished the ulcer index and enhance % protection in ulcer compared with control and standard (ranitidine - 20mg/kg) treated group in ethanol and pylorus model. Conclusion: The observations conrmed that the antiulcer activity of the combined methanolic extract may be attributed to the presence of active constituents like curcumin, piperine and berberine in the plant extract.
